The purpose of this study was to test the direct and moderating effects of job strain variables on the Job Demand–Control–Support model. A total of 422 tourism employees completed a questionnaire. Hierarchical and moderated regression models were employed to test the proposed relationships between job strain variables and work‐to‐leisure conflict. Results indicated that job demands had a positive relationship with work‐to‐leisure conflict, whereas the schedule flexibility and the time‐off flexibility were negatively related to work‐to‐leisure conflict. Results also found that supervisor support could moderate the influence of tourism employees' job demands on work‐to‐leisure conflict. Implications of stress management and job design for human resource department are discussed. Copyright © 2013 John Wiley & Sons, Ltd.