This paper reports the results of a study that examined the impact of a culture-based entrepreneurship study abroad program on student interest in business ownership. Ninety-six students were asked to complete a pre-and post-study abroad program questionnaire that asked about their understanding of a variety of program activities and to gauge their interest in starting a business. Little similar research has been reported in the literature. Pre- and post- program mean rankings of the variable are reported. The results indicated that post-program mean ranking of knowledge, understanding, and skill ability variables tend to be higher than pre-program mean rankings. Fifteen of the 22 post-program mean values of the measured variables are significantly different from pre-program mean values. Logit regression analysis indicated that the language and program structure variables were positively associated with interest in starting a business while the Spanish business and entrepreneurial skills were negatively associated with business ownership. The results of this study may be of interest to educators involved in developing entrepreneurship and study abroad courses and programs. The study may be of special interest to those involved in developing integrative entrepreneurship programs.