This article examines park use in relation to neighborhood social (safety and poverty) and urban form (pedestrian infrastructure and street network pattern) characteristics among youth and adult subpopulations defined by age and gender. We utilized System for Observing Play and Recreation in Communities (SOPARC) and Geographic Information Systems to objectively measure park use and park and neighborhood characteristics in 20 neighborhood parks. Heterogeneous negative binomial regression models indicated that the relationship between park use and types of activity settings, and park use and neighborhood attributes vary by age and gender. In general, the study found that park and activity setting size; activity settings such as playgrounds, basketball courts, pool and water features, shelters, and picnic areas; and availability of sidewalks and intersections in the park’s neighborhood were positively associated with park use, whereas crime, poverty, and racial heterogeneity of the surrounding neighborhood were negatively associated with park use.