This article borrows from the intersectionality literature to investigate how legal status, labor market position, and family characteristics structure the labor supply of immigrant Latinas in Durham, North Carolina, a new immigrant destination. The analysis takes a broad view of labor force participation, analyzing the predictors of whether or not women work, whether and how the barriers to work vary across occupations, and variation in hours and weeks worked among the employed. I also explicitly investigate the extent to which family constraints interact with other social characteristics, especially legal status, in shaping women’s labor market position. Results highlight that immigrant Latinas experience multiple, interrelated constraints on employment owing to their position as low-skill workers in a labor market highly segregated by gender and nativity, as members of a largely undocumented population, and as wives and mothers in an environment characterized by significant work–family conflict.