This article questions the popular assumption that the concept of civilization that entered public discourse in a grand way with Samuel P. Huntington’s sensational article on a ‘clash of civilizations’ refers to any meaningful historical formations that can be identified across time and space in plural manifestations, apparently withstanding collapse, disintegration and a final withering away. Contrasting Huntington’s rather stable universe with A. J. Toynbee’s and Eric Voegelin’s radically different perspectives on an open-ended dynamics of civilizational processes makes it possible to recognize that the sequence of institutional cycles and the succession of universes of symbolic meaning that accompany them may be limited. Civilizations are not natural phenomena but human constructs and have therefore limited timelines. Toynbee and Voegelin were facing an end of the history of traditional civilizations and all their pseudo-morphed variations. They envisioned something new would emerge out of the wasteland of meaning without clearly knowing what it would be. The political economy of globalization has certainly accelerated the terminal conditions of traditional civilizations that Toynbee and Voegelin had anticipated long before this modern endgame began. The signs of decay and death are overwhelming while the quests for a new universe of meaning are still in their infancy.