The epistemology of the life sciences has significantly changed over the last two decades but many of these changes seem to remain unnoticed amongst sociologists: both the majority who reject biology and the few minorities who want to biologize social theory seem to share a common (biologistic) understanding of ‘the biological’ that appears increasingly out of date with recent advances in the biosciences. In the first part of this article I offer an overview of some contemporary importations of biological and neurobiological knowledge into the sociological field. In the second section I contrast this image of biological knowledge circulating in the social sciences with the more pluralist ways in which biology is theorized in many sectors of the life sciences. The ‘postgenomic’ view of biology emerging from this second section represents a challenge for the monolithic view of biology present amongst social theorists and a new opportunity of dialogue for social theorists interested in non-positivist ways of borrowing from the life sciences.