This article presents a cultural analysis of HBO’s drama series, The Wire. It is argued here that, as a cultural text, The Wire forms a site of both containment and resistance, of hegemony and change with recourse to the regulation of illicit drug markets. In this sense The Wire constitutes an important cultural paradigm of drug policy debates, one that has significant heuristic implications regarding both the present consequences and future directions of illicit drug policy. Ultimately, it is demonstrated below that through its representations of the tensions and antagonisms characteristic of drug control systems, The Wire reveals larger predicaments of governance faced by neoliberal democracies today.