This study explores patterns among female family annihilators using a non-random sample (n = 7), where offenders killed four or more family members during a single homicidal event. Acts of maternal familicide are measured against the family annihilator profile. Overall, many variables remain consistent across gender, but there appear to be substantive differences in motivation, spousal murder attempt, and the role of alcohol. Findings suggest that research on the family annihilator needs to be more inclusive of women, including use of more gender-neutral language. Practical and theoretical implications are discussed, and a new definition of the family annihilator is offered.