In a sample of 484 emerging adults in dating relationships, we tested whether four intrapersonal characteristics (masculinity, femininity, neuroticism, and co-rumination) moderated the association between relationship satisfaction and depressive symptoms. Femininity demonstrated a moderating effect for women only; relationship satisfaction and depressive symptoms were more strongly associated in women with higher, versus lower, femininity. Co-rumination had a moderating effect for both sexes; relationship satisfaction was more strongly associated with depressive symptoms for individuals with higher, versus lower, levels of co-rumination. No moderating effects were found for masculinity or neuroticism. Findings support clinical and feminist theories that high femininity may place women at risk of dysphoric reactions to relationship distress and suggest that co-rumination may represent a risk factor for depression.