While a growing body of literature addresses the experience of migrant women’s involvement in self-employment, this work has focused on relatively few groups and has emphasized gender to the neglect of other contextual factors, such as family, class and ethnic resources, structures of opportunity and the nature of migrants’ relations with networks in countries of origin and settlement. In this article, I draw on multi-sited ethnography to explore Vietnamese, Russian-speaking Jewish, and Israeli women immigrants’ patterns of self-employment. Results suggest that contrary to being an end in itself, in most cases self-employment is simply a strategy that immigrant women engage in to obtain income while coping with an array of opportunities, impediments, and obligations framed by the structure of opportunities and disadvantages as well as transnational concerns.