Using a social cognitive career theory perspective, the relationships among self-efficacy, coping styles, and job satisfaction were examined in a sample of 314 nurses employed in regional hospitals in Taiwan. Results indicated that self-efficacy was positively associated with problem-focused coping style and job satisfaction and negatively associated with emotion-focused coping. The influence of self-efficacy on job satisfaction was indirect and partially mediated by coping styles. Psychologists and health care managers may use these findings to design relevant intervention programs to enhance nurses’ coping effectiveness and self-efficacy.