This article addresses gender differences in the extent and explanation of inmate misconduct. The study employs nationally representative prisoner survey data to assess gender-specific explanations of prison rule violations. The gender-specific factors include prior victimization, diagnosed mental disorders, and the amount of inmate contact with their families via visits and phone calls. Logistic regression models support gender-specific explanations of inmate misconduct but also identify other factors of general importance. The policy implications of gendered pathways in prison misconduct are discussed.