Meta-analysis was employed to investigate the relationship between personality constructs of the five-factor model (FFM) and difficulties in career decision making (DCDM). Twenty studies with one to five quantitative FFM constructs were selected for review. The present study found evidence that the traits of the FFM of personality can predict DCDM. There was a statistically significant positive relationship between Neuroticism and DCDM, and statistically significant negative relationships between Agreeableness, Conscientiousness, Extraversion, and Openness. Mean effect sizes were small (<.30) with Neuroticism being the highest, closely followed by Conscientiousness, and with Agreeableness being the lowest. Both age and nationality of sample were found to be significant moderators of FFM constructs and DCDM. The discussion includes implications for research and practice.