Participation in regular physical activity promotes physical health and psychosocial well-being. Interventions are thus needed to promote physical activity, particularly among groups of individuals, such as persons with disability, who are marginalised from physical activity. This study explored the experiences of a group of South African adolescents with cerebral palsy. In-depth semi-structured interviews were conducted with 15 adolescents with cerebral palsy. The results provided insight into a range of factors that promote and hinder participation in physical activity among adolescents with cerebral palsy in resource-scarce environments.