Quality of life (QoL) for persons with Autism Spectrum Disorders (ASD) and factors associated with QoL are not well understood. Prior literature has relied on parent-report though this is changing. It may be important to consider both parent-reported QoL and self-report. This study explored QoL in 22 Canadian adolescents (3 girls, 19 boys) ages 13 to 18 years (M = 15.2 years). Adolescents completed the 10 subscales of the KIDSCREEN-52, a standardized questionnaire, while their parents completed the proxy form of the measure and the Adaptive Behavior Assessment System–II. Both parents and adolescents reported mean QoL scores in the lower average range. Intra-class correlation coefficients between parent and self-report were similar to adolescents without special needs except for four subscales. Correlations between QoL and the General Adaptive Composite score were remarkably low. Adolescents with ASD respond differently from their parents in some areas and both reports should be considered.