This two-wave longitudinal study investigated the reciprocal relations between five possible predictors of career calling (presence of life meaning, search for life meaning, career decision self-efficacy, personal growth initiative, and intrinsic religiousness) among a sample of undergraduate college students over a 6-month period. Using structural equation modeling, two models were tested. The first model included all five predictor variables and was a poor fit for the data; the second model included only search for life meaning and personal growth and displayed improved model fit. Results from the second model indicated that search for life meaning and personal growth at Time 1 significantly predicted calling at Time 2, whereas calling at Time 1 was a nonsignificant predictor of either Time 2 outcomes. These findings suggest the more one is searching for his or her meaning in life and intentionally engaging in self-improvement, the more likely she or he is to later experience a calling.