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Flow time through esophagogastric junction derived during high-resolution impedance-manometry studies: a novel parameter for assessing esophageal bolus transit

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AJP Gastrointestinal and Liver Physiology

Published online on

Abstract

This study aimed to develop and validate a method to measure bolus flow time (BFT) through the EGJ using a HRIM sleeve. Methods: 10 healthy subjects were studied with concurrent HRIM and videofluoroscopy while another 15 controls underwent HRIM alone. HRIM studies were performed using a 4.2 mm outer diameter assembly with 36 pressure sensors (1-cm intervals) and 18 impedance segments (2-cm intervals) (Given Imaging, Los Angeles, CA). HRIM and fluoroscopic data from 4 barium swallows (2 supine; 2 upright) were analyzed to create a customized MATLAB program to calculate the BFT using a HRIM sleeve comprised of 3 sensors positioned at the crural diaphragm (CD). Results: Bolus transit through the EGJ measured during blinded review of fluoroscopy was almost identical to the BFT calculated with the HRIM sleeve using the nadir impedance deflection point as the signature of bolus presence. Good correlation existed between videofluoroscopy for measurement of upper sphincter relaxation to beginning flow (supine, R=0.97, P<0.001; upright, R=0.77, P<0.01) and time to end of flow (supine. R=0.95, P<0.001; upright, R=0.82, P<0.01). The median (IQR) of Flow Time though the EGJ in 15 healthy subjects calculated using the virtual sleeve was 3.5 s (2.3-3.9 s) in supine position and 3.2 s (2.3-3.6 s). Conclusions: BFT is a new metric that provides important information on bolus transit through the EGJ. An assessment of BFT will determine the time period where the EGJ is open and also provide a useful method to accurately assess trans-EGJ pressure gradients during flow.