This study examined the associations between individual, institutional, and cultural race-related stress and somatic and cognitive anxiety. We adopted a risk and resilience framework to investigate the protective role of optimism and religious involvement in the race-related stress-anxiety link. A total of 171 African American young adults completed measures of race-related stress, optimism, religious involvement, and anxiety symptomatology. Institutional race-related stress was positively associated with cognitive and somatic anxiety. Optimism moderated the association between individual race-related stress and cognitive anxiety. Religious involvement enhanced the protective function of optimism in the association between individual and cultural race-related stress and cognitive anxiety. These results illustrate the utility of a multidimensional framework for understanding the impact of race-related stress on anxiety symptomatology. Moreover, the pattern of findings suggests that high religious involvement and high optimism may produce the most advantageous outcomes with respect to the association between race-related stress and anxiety in African American young adults.