ObjectiveHematopoietic stem cell transplantation (HSCT) is curative in several life‐threatening pediatric diseases but may affect children and their families inducing depression, anxiety, burnout symptoms, and post‐traumatic stress symptoms, as well as post‐traumatic growth (PTG). The aim of this study was to investigate the co‐occurrence of different aspects of such responses in parents of children that had undergone HSCT. MethodsQuestionnaires were completed by 260 parents (146 mothers and 114 fathers) 11–198 months after HSCT: the Hospital Anxiety and Depression Scale, the Shirom–Melamed Burnout Questionnaire, the post‐traumatic stress disorders checklist, civilian version, and the PTG inventory. Additional variables were also investigated: perceived support, time elapsed since HSCT, job stress, partner‐relationship satisfaction, trauma appraisal, and the child's health problems. A hierarchical cluster analysis and a k‐means cluster analysis were used to identify patterns of psychological responses. ResultsFour clusters of parents with different psychological responses were identified. One cluster (n = 40) significantly differed from the other groups and reported levels of depression, anxiety, burnout symptoms, and post‐traumatic stress symptoms above the cut‐off. In contrast, another cluster (n = 66) reported higher levels of PTG than the other groups did. ConclusionsThis study shows a subgroup of parents maintaining high levels of several aspects of distress years after HSCT. Differences between clusters might be explained by differences in perceived support, the child's health problems, job stress, and partner‐relationship satisfaction. Copyright © 2014 John Wiley & Sons, Ltd.