ObjectiveAlthough enhanced spiritual well‐being has been linked to positive mental health outcomes among family caregivers of cancer patients, little is known regarding predictors of spiritual well‐being in this population. The current study aimed to examine caregiving experiences as predictors of change in family caregivers' spiritual well‐being during the initial months following the patient's cancer diagnosis. MethodsSeventy family caregivers of newly diagnosed cancer patients (74% female, mean age = 59 years) participated in this longitudinal survey. Caregivers completed baseline questionnaires shortly before staying with the patient at an American Cancer Society Hope Lodge. Baseline questionnaires assessed caregiving experiences (i.e., self‐esteem related to caregiving, family support for providing care, impact of caregiving on finances, and impact of caregiving on one's schedule). In addition, caregivers' spiritual well‐being (i.e., meaning in life, peace, and faith) was assessed at baseline and 4‐month follow‐up. ResultsIn univariate analyses, all caregiving experiences studied were associated with one or more aspects of spiritual well‐being at 4‐month follow‐up. However, in the multivariate analysis, the only caregiving experience associated with aspects of spiritual well‐being at 4‐month follow‐up was caregivers' perceptions of family support. Specifically, lack of family support was associated with lower levels of meaning and peace. ConclusionsFindings point to the importance of family support in facilitating the search for meaning and peace shortly after a loved one's cancer diagnosis and suggest that interventions targeting caregivers' support system may enhance their spiritual well‐being. Copyright © 2014 John Wiley & Sons, Ltd.