This study examined the role of compassionate love (CL) in shaping cognitive, emotional, physiological, and behavioral responses to partner distress (N = 56 couples). One member of each couple (the support provider) observed his/her partner perform an easy or difficult stress task (designed to vary signals of partner distress). Support providers in the difficult (vs. easy) condition showed more partner focus, emotional distress, and blood pressure reactivity during the task and expressed more support afterward. Support providers high (vs. low) in CL showed greater partner focus and emotional empathy and sent more caring messages. Additional analyses suggest that CL increases sensitivity to a partner’s distress and that the link between CL and support behavior is mediated by increases in empathy and attention to one’s partner.