Reputation-seeking can explain some decisions of U.S. federal agencies. However, it has remained unclear whether it could be used in the European context where agencies have proliferated in national and regional governance in the past few decades. This article shows that reputation-seeking can occur at autonomous agencies in the European context. A unique participant-observational study of an international public health agency acting in response to the 2009 H1N1 "swine" influenza pandemic provides bases for this conclusion. It adds empirical support for the proposition using real-time observations of and in-depth interviews on the agency’s decision-making processes.