The study sought to ascertain the factors influencing knowledge application in Ghanaian industries. The study employed a survey technique as the research design. Purposive and snowball sampling techniques were used to select 300 respondents. Questionnaire was the main data collection tool. Data was analysed using descriptive statistics and factor analysis. The study found that organizational culture, trust and absorptive capacity are the factors influencing knowledge application in Ghanaian industries. The strategic implications of the findings are discussed in the paper.