The demographic variables of employees have been noted as important determinants of their commitment to work. This paper reports empirical research findings on the relationship between the demographic factors of medical records management personnel at the Korle-Bu Teaching Hospital (KBTH) in the Greater Accra Region of Ghana, and their commitment to work, and proposes recommendations based on the findings. The study was quantitative. One hundred and six (106) copies of a questionnaire were administered to the 106 medical records personnel in the 28 clinical departments of the KBTH, and 92 (87 percent) were obtained in complete form and used for the analysis. Regression analysis was used to investigate the extent to which the demographic variables of the respondents determined their organizational commitment. The key finding of the study was that positive relationships exist between demographic variables (age, gender, job tenure, educational level) and organizational commitment of medical records personnel at KBTH. The findings indicate the need for the management of KBTH to consider the demographic factors of the medical records staff in an attempt to improve their commitment to work.