The humor utilized by Quino and Lat, cartoonists who belong to cultures that are far apart, is the starting point of this work. This investigation analyzes the topic of politics viewed from these two different cultural backgrounds and therefore from two different perspectives. The researchers seek to go more deeply into the topic of politics, and aim to uncover the differences and similarities in the way these two artists approach this subject through the use of humor, specifically in four of their cartoons. The main findings are that Quino’s approach can be considered universal, while Lat’s approach tends to be more localized. It is found that cultural predispositions make humor social by nature. Neither of the artists seeks social change through their work, but rather social awareness.