Using data collected on tenure-line faculty at a research-intensive Midwestern university, this study explored predictors of faculty job turnover intentions due to a desire for a better work–family balance. We adopted Voydanoff’s theoretical framework and included demands and resources both within and spanning across the work and family domains. Results showed that work-related demands and resources were much stronger predictors of work–family turnover intentions than family-related demands or resources. Specifically, work-to-family negative spillover was positively associated with work–family turnover intentions, and two work-related resources (job satisfaction and supportive work–family culture) were negatively associated with work–family turnover intentions. On the other hand, family-related demands and resources (within the family domain or boundary-spanning from family to work) did not significantly predict work–family turnover intentions.