Purpose: The purpose of this study was to determine the validity and reliability of the Tilburg Pregnancy Distress Scale–Turkish version (TPDS-T). Methods: The sample consisted of 214 healthy pregnant women in maternity clinics in an urban center in western Turkey. The instruments included a demographic questionnaire and TPDS-T. Results: The internal consistency reliability coefficient of the TPDS-T was .70. The correlation coefficients between the lower dimension item scores and lower dimension total scores were .20 to .73. According to the confirmatory factor analysis, the model fit indexes of the scale were determined as root mean square error of approximation = .051, goodness-of-fit index = .91, comparative fit index = .92, and nonnormed fit index = .90. Conclusion: The TPDS-T is a valid and reliable scale that can be used to determine distress of pregnant women in Turkey. Implications for Practice: This scale can be used as a guide by Turkish midwives and obstetric nurses planning pregnancy follow-up care.