A crucial point of debate around the construct of self-leadership is its supposed lack of distinctiveness from other theoretically related constructs. We empirically investigate in professionals with leadership experience (N = 374) with a bifactor structural equation modeling approach to what extent self-leadership (a) is distinct from related classic motivation constructs (need for achievement, self-regulation, self-efficacy) and (b) harbors incremental predictive validity over and above these motivation constructs in predicting individual job performance and leadership behavior styles (transformational leadership, transactional leadership, laissez-faire leadership). Findings yielded that self-leadership (a) generally showed only moderate associations with constructs of classic motivation literature and was sufficiently distinct from them and (b) could incrementally predict outcomes above and beyond related classic motivation constructs, alluding to its uniqueness. We discuss self-leadership as a unique and useful construct worthy of own systematic research.