This study investigates the impact of The Personal Strengths Program (PSP) on seven college students with learning disabilities and/or attention deficit hyperactivity disorder (LD/ADHD) using a multiple baseline design. Students with LD/ADHD experience increased challenges in school settings and decreased post-secondary outcomes when compared with their peers without disabilities. Research has indicated that students who are able to transition into post-secondary settings successfully often have higher levels of self-determination than those who do not transition as successfully. PSP is grounded in effective teaching practices for students with LD/ADHD, self-determination, and positive psychology. It utilizes guided cognitive strategy instruction to assist students in identifying and using their strengths to achieve their goals related to their academic classes. Results were mixed, but do suggest there is some effect from participating in PSP on self-determination levels. Implications for students with LD/ADHD and researchers conducting intervention studies are discussed.