The emerging discourse on science in social work (SW) has generated much-needed analysis of the profession’s status as a scientific enterprise. Brekke raised critical issues that must be addressed for SW to become a science. This response examines the contextual factors that led to the call for SW science. It also relies on a comparative analysis of attempts by other professions and disciplines to become scientific to discuss critical challenges and opportunities for SW to evolve to science status in the highly contentious scientific environment of the 21st century.