In the late nineteenth and early twentieth century, the Peruvian Andes ranked as a key international destination for those afflicted with one of the world’s most deadly diseases, tuberculosis. Physicians, scientists, policy makers, and patients believed that high-elevation mountain climates worldwide would help cure the disease. Historical processes driving the creation of Andean health resorts, which are understudied in the historiography, uncover an important story in the history of tuberculosis, and also reveal how global health initiatives and disease treatment played out within the global South, where national forces and local environmental conditions influenced the trajectory of science and medicine. Jauja, Peru, became an internationally recognized health resort for tuberculosis treatment not only through science and medicine but also through national political integration campaigns, transportation initiatives, economic development agendas, social (race and class) relations, cultural perspectives of the Andean landscape, and the impact of the physical environment. This historical case about the evolution of Jauja reveals how science and medicine are shaped by distinct spatial forces that illuminate a geography of science in the postcolonial setting, as well as the ways in which climate is culturally constructed in specific sites, by different peoples, and at distinct points in time.