The article explores the perspectives of Foucault’s notion of government by linking it to the debate on the ‘new materialism’. Discussing Karen Barad’s critical reading of Foucault’s work on the body and power, it points to the idea of a ‘government of things’, which Foucault only briefly outlines in his lectures on governmentality. By stressing the ‘intrication of men and things’ (Foucault), this theoretical project makes it possible to arrive at a relational account of agency and ontology, going beyond the anthropocentric limitations of Foucault’s work. This perspective also suggests an altered understanding of biopolitics. While Foucault’s earlier concept of biopolitics was limited to physical and biological existence, the idea of a ‘government of things’ takes into account the interrelatedness and entanglements of men and things, the natural and the artificial, the physical and the moral. Finally, the conceptual proposal of a ‘government of things’ helps to clarify theoretical ambiguities and unresolved tensions in new materialist scholarship and allows for a more materialist account of politics.