This paper uses Guangzhou’s experience of hosting the 2010 Asian Games to illustrate Guangzhou’s engagement with scalar politics. This includes concurrent processes of intra-regional restructuring to position Guangzhou as a central city in south China and a ‘negotiated scale-jump’ to connect with the world under conditions negotiated in part with the overarching strong central state, testing the limit of Guangzhou’s geopolitical expansion. Guangzhou’s attempts were aided further by using the Asian Games as a vehicle for addressing condensed urban spatial restructuring to enhance its own production/accumulation capacities, and for facilitating urban redevelopment projects to achieve a ‘global’ appearance and exploit the city’s real estate development potential. Guangzhou’s experience of hosting the Games provides important lessons for expanding our understanding of how regional cities may pursue their development goals under the strong central state and how event-led development contributes to this.