There is a paucity of studies analysing the role of ethnobotanical knowledge for handicraft and local development. Thus, more work is required to expand the range of detailed case studies on which to draw. The objective of this article is to analyse an initiative promoted by a pioneering experience of its kind in the Araucaria region, Chile, which is centred on traditional knowledge of Mapuche communities. By identifying what lessons can be drawn from this experience, this study analyses the factors that can promote synergies between handicraft and conservation of local plants from which resources are derived for handicraft.