This study explores the relative influence of geographical and cognitive proximity to explain innovation performance. This paper deepens the controversy between the significance of both types of proximity, contributing to a better understand their interconnections. The study further analyzes to what extent knowledge acquisition provides a congruent explanation of the effectiveness of innovation in proximity contexts. The paper has tested a structural model based on a sample of 224 Spanish footwear firms. Footwear industry is a mature and traditional industry with a significant presence of the territorial agglomeration of firms all over Spain. Findings suggest both a direct and indirect effect of cognitive proximity on innovation performance. However, an excess of geographical proximity produces spatial lock-in, thus limiting the access to new knowledge and lowering innovations. By contrast, proximity in terms of goals and culture leads firms belonging to a territorial cluster to achieve knowledge acquisition resulting in relevant innovation. Findings suggest that although transferable valuable knowledge exists in clustered contexts firms should adopt a proactive behavior to have access common knowledge and in order to generate effective innovations.