Scientific results are always afflicted with some uncertainty, especially where emerging technologies are concerned. While there are normative and practical reasons to call for an open admission of scientific uncertainties, concerns about detrimental effects of such communication on public engagement with science have been raised in the literature. The present study was conducted to investigate how the communication of scientific uncertainty in nanotechnology influences laypeople’s interest in science and new technologies, beliefs about the nature of science, and trust in scientists. In a longitudinal field experiment, 945 participants were exposed to six real-world media reports (TV features and newspaper articles) on nanotechnology. Contrary to our expectations, the communication of scientific uncertainties was unable to change general beliefs about the nature of science. However, it had no detrimental effect on the trust in scientists, and with respect to interest in science and new technologies, slightly positive effects were observed.