Understanding the primary triggers of anxiety for African Americans, and the cultural factors associated with these triggers, can enhance our knowledge of emotional responding in African Americans and can ultimately influence how we assess and treat anxiety disorders in this population. In the current study, we investigated the experience of anxiety for African Americans following physical stressors, with an emphasis on cardiovascular arousal. Specifically, anxious responding, following cardiovascular arousal, other physical stressors, and a control task, was evaluated among African American (n = 23) and European American (n = 23) groups on affective, cognitive, and physiological measures of anxiety. Findings suggest physical stressors in general (as opposed to cardiovascular arousal specifically) may be a prominent trigger of anxiety for African Americans. Discussion centers on the idea that the observed relationship between anxiety and physical stressors for African Americans may stem from a cultural sense of vulnerability regarding physical disease.