This study advances anomie theory by examining the effect of anomic societal conditions and indicators of globalization on national homicide rates. Globalization may generate anomie in two ways: (a) via rapid change and (b) by contributing to economic dominance that may lead to a chronic state of anomie. To assess the role of globalization, measures of international trade are examined in a model of national homicide rates. Results show that net investment has a positive effect on rates of homicide across several models, suggesting that globalization and economic dominance aggravate homicide.