Core countries, such as the United States, have created economic and trade policies which encourage Latino migration for cheap, exploitable labor and new demands for Latino sex trafficking within the United States to serve new destination male migration communities. This theory-building exercise utilizes world system and intersectional theoretical frameworks to examine the implications of geo-political policies and unequal development on lived experience affected by the intersection of massive Latino migration; poverty; gender inequalities and vulnerabilities; and Latino sex trafficking. A feminist political economy theoretical analysis is essential to a more sophisticated understanding of the historical socio- and geo-political effects of hegemonic modern world system core policies on new destination Latino migration and the lives of Latina women trafficked for sexual exploitation.