The present study tested the impact of religiosity and region on lethal violence in 83 countries by applying an integrated model. The regression results provided support for Durkheim’s proposition that religious passion might lead to a high homicide rate in a society. However, religiosity was significantly and negatively connected to the suicide rate, suggesting that religious secularization is related to an increased national suicide rate. Finally, the Latin American region exhibited an elevated homicide rate, while North Africa and the Middle East displayed low homicide and suicide rates.