At present, the average homicide clearance rate in the United States is approximately 65%, down roughly 15% from the mid-1970s. This research seeks to inform how police can best improve homicide clearance rates by identifying best practices in homicide investigations. To accomplish this goal, as part of a federally funded project, seven geographically representative law enforcement agencies were identified that had at least 24 homicides in 2011 and had a clearance rate of 80% or higher from which effective investigative practices could be gleaned. Qualitative findings indicate that a strong community policing presence, collaboration with external agencies, and an innovative culture facilitate high rates of homicide clearance. Implications for policy and future research are discussed.