Objective: Studies on protective factors for school victimization are rare and usually focus on specific assets. The current study examined the association between quantity and variety of domains of developmental assets and school victimization in adolescence. Method: Data were drawn from the California Healthy Kids Survey (CHKS; N = 11,790 high school students attending 17 schools). The Social and Emotional Health Survey–Secondary (SEHS-S) was administered as part of a federally funded school climate initiative in the spring of 2013. A mixed-effects modeling approach tested associations between configurations of assets and school victimization. Results: Adolescents reporting a higher quantity of assets in multiple domains had a lower likelihood of experiencing physical and relational victimization and fear of being victimized in school compared to youth having zero assets. Conclusions: Results supported the importance of considering the quantity of psychological and social assets and also the variety of assets across multiple domains. Interventions promoting multiple protective factors in multiple areas of youths’ lives may have the highest likelihood of impacting adolescent well-being. (PsycINFO Database Record (c) 2015 APA, all rights reserved)