We recruited 110 college students for an experimental investigation of the role of guilt in motivating religious behavior. We induced guilt in half of the participants before asking all subjects to indicate their current interest in prayer. Overall, participants in the guilt condition were more interested in praying, but this effect was not observed among those high in grandiose narcissism. Our findings make a contribution not only to the study of the role that emotions have in motivating religious behavior, but also to the study of narcissists’ susceptibility to guilt.