Modulation of the autonomic nervous system on heart rate can be compromised in chronic kidney disease and may result in changes in the frequency and duration of the cardiac cycle. The aim of this study was to evaluate autonomic modulation in active and sedentary renal transplant recipients. 20 renal‐transplanted individuals were analyzed at the Centro de Prevenção de Doenças Renais (Kidney Disease Education Center), in the academic hospital of Universidade Federal do Maranhão, divided into active group (AG) and sedentary group (SG). The AG group was in regular concurrent training intervention for eight weeks, involving six men and four women (age 43.10 ± 13.02) while the SG was composed of three men and seven women (age 36.8 ± 9.26). Analysis of heart rate variability in time and frequency domain demonstrated that HR mean values in the SG and AG groups were 787.32 ±79.60 and 870±106.66ms, respectively. Differences were observed in time domain (SDNN, RMSSD) and frequency domain (LF (%), HF (%) and LF/HF). Total index of LF (m²) and HF (m²) has shown no differences for the SG and AG groups. Biochemical variables presented significantly lower levels after eight weeks of training. Higher heart rate variability in time domain and greater vagal modulation was observed in the AG group. The AG group had greater vagal modulation when compared to SG, with removal of the sympathetic and increased parasympathetic in the behavior [A FRASE EM VERMELHO NÃO FEZ SENTIDO] was confirmed by sympatho‐vagal balance. The AG group also presented significant improvements in frequency domain. This article is protected by copyright. All rights reserved.