The need exists for a comprehensive literature review of the concept of mattering with regard to work. In response, this review examined a theoretical framework of societal and interpersonal mattering, mattering within the work context, and existing psychometric measures of mattering. The author analyzed the research on the current state of mattering at work, identified core frameworks and psychometric issues that have been investigated to date, and suggests the use of a more comprehensive framework for work mattering that illuminates both the relational and social aspects of the work experience. Several promising directions for future research and potential benefits of incorporating work mattering in career counseling practice emerged and are discussed.