The present study examined the differences in the experience of a calling among working adults in the Unites States and India. First, we examined group differences in perceiving a calling and living a calling between Americans and Indians, with Indians being more likely to endorse perceiving and living out a calling than Americans. Second, we tested a moderated, multiple mediator model to investigate the mediating role of life meaning and job satisfaction in the relation of living a calling to life satisfaction and the moderating role of nationality. Supporting prior research, both life meaning and job satisfaction were found to mediate the relation between living a calling and life satisfaction. Furthermore, we found that nationality moderated the living calling–life meaning and living calling–job satisfaction links. These results indicate the importance of nationality in the link between living a calling and life satisfaction. Implications for research are discussed.