The present study examined the relations between work stress and both the presence of and search for meaning in life. Three components of meaningful work—positive meaning, meaning-making, and greater good motivations—were investigated as potential moderators. As hypothesized, work stress had a significant, negative relation with the presence of meaning in life, and a significant, positive relation with the search for meaning in life. Furthermore, the meaning making component of meaningful work moderated the relation between work stress and the presence of meaning in life. Specifically, meaning making served as a buffer where greater meaning making at work was associated with weaker relations between work stress and the presence of meaning in life. None of the three components of meaningful work moderated the relation between work stress and the search for meaning in life. Practical implications and directions for future research are discussed.