Given the complexities of today’s workplace, organizations and agencies are progressively turning toward interdependent systems comprised of teams, or multiteam systems (MTSs), to accomplish multifaceted tasks in challenging environments. Subsequently, MTSs have grown in popularity in group and team research, spanning a breath of disciplines (psychology, organizational behavior, human factors, communication, and medicine). In this review, our goal is to highlight the existing research across a range of disciplines regarding MTSs that serves to answer the question, "What do we know about MTSs?" while also developing a future research agenda aimed at answering the question, "Where does our research need to go to better understand MTSs?" We specifically highlight the current trends, dynamics, and methodological issues in MTSs to further build the foundation for improving MTS effectiveness.