The Drinking Motives Questionnaire, previously postulated and documented to exhibit a measurement structure of four correlated factors (social, enhancement, conformity, and coping), is a widely administered assessment of reasons for consuming alcohol. In the current study (N = 552), confirmatory factor analyses tested the plausibility of several theoretically relevant factor structures. Fit indices corroborated the original four-factor model, and also supported a higher-order factor model involving a superordinate motives factor that explicated four subordinate factors. A bifactor model that permitted items to double load on valence type (positive or negative reinforcement) and source type (external or internal) generated mixed results, suggesting that this 2 x 2 motivation paradigm was not entirely tenable. Optimal fit was obtained for a bifactor model depicting a general factor and four specific factors of motives. Latent factors derived from this structure exhibited criterion validity in predicting frequency and quantity of alcohol usage in a structural equation model. Findings are interpreted in the context of theoretical implications of the instrument, alternative factor structures of drinking motives, and assessment applications.