Objective The overarching purpose of this study was to explore the relationships among acculturative stress, self‐esteem, and eating pathology in Asian American and Latina female college students. Method Participants (N = 638, mean age = 19.88) completed self‐report measures of the variables of interest online. Results Bivariate correlations indicated that for women of both ethnic groups, acculturative stress was negatively correlated with self‐esteem and positively correlated with eating pathology. Multigroup structural equation modeling indicated that for Asian American and Latina women, self‐esteem partially mediated the relationship between acculturative stress and eating pathology. However, self‐esteem did not serve as a significant moderator of this relationship for either ethnic group. Conclusion Overall, data suggest that acculturative stress is associated with increased eating pathology and self‐esteem may mediate this relationship. These relationships suggest that assessment of eating pathology and self‐esteem may be indicated for women presenting clinically with acculturative stress concerns.